Café Variome v4

Federated discovery engineered for the next decade

At a glanceBy design
LocalData custody
3Disclosure levels
FederatedQuery model
Secure discoveryIllustrative network
Federated data networkA researcher sends a query through Café Variome to three connected data sources while the data remains local.ResearcherPolicy layer

Café Variome v4

A new approach putting you in control

  • Control your response
  • Models that adapt to your data
  • Discover across networks with confidence
Adaptive privacyZero trust data ingestion
How it works

Designed for data custodians and researchers

Federated by design

Researchers can search across connected resources from one place while data stays within the systems that manage it.

  • Queries travel to participating data sources
  • Local teams retain custody and oversight
  • Networks can grow without centralising data

Privacy that responds to context

Configure access and disclosure for different users and groups, then return only the level of detail you approve.

  • Set permissions for users and groups
  • Control the detail returned by each query
  • Support discovery without exposing source data

Flexible integration

Connect Café Variome to existing research infrastructure and shape the discovery experience around each network.

  • Integrate with existing data services
  • Support different research data models
  • Create focused discovery networks
Trusted by

Driving national and international collaboration

Leading research networks and national initiatives rely on Café Variome to collaborate securely across borders.

EPND

European Prevention of Neurodegenerative Diseases

Federated discovery across longitudinal cohorts to accelerate neurodegeneration research.

LHIS

Leicestershire Health Informatics Service

Discovery of patient health data for research without compromising privacy.

Research Networks

Mitomatcher

Supporting mitochondrial variant sharing.

Café Variome logo

Café Variome

Future-proof federated discovery.

© 2026 Café Variome Consortium. Built for equitable discovery.